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However, it has been suggested that this classificationwould be less useful for classifying osteomyelitis in diabetic patients, especially in case ofinvolvement of the small bones in the foot than in patients with posttraumatic osteomy-elitis [7]. Blood tests were unremarkable: WBC counts 7.4g/l (normal 4–10g/l), CRP6mg/l (normal <5mg/l). Consistentwith its role in regulating mitochondrial GSH (mGSH) buy isotretinoin for acne mitochondrial cholesterolaccumulation emerges as a key factor regulating ROS and electrophile detoxification, andhence disease progression by sensitizing to secondary hits such as TNF, hypoxia or toxicamyloid peptides. As noted in the previous chap-ter, Heather and her Chinese roommate “Rita” regularly and openly jokedabout contracting the disease—“Ha ha ha: you’ve got SARS”—in response tocoughing. For example, if the disease primarily affectsthe hippocampal system then the cognitive profi le shouldreflect a primary episodic memory deficit

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