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As mentioned above, limitingIL-2 availability during the early stages of an immune response by Tregs insures thedifferentiation of CD4 T cells into TH(fh) cells and therefore, the secretion of antigen (viral)specific antibodies occurs rapidly. It combines with 50S ribo-some subunits and interferes with ‘translocation’(see Fig It combines with 50S ribo-some subunits and interferes with ‘translocation’(see Fig.
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Lymphoid tissue and blood cellsGlucocorticoids enhance the rate of destructionof lymphoid cells (T cells are more sensitive thanB cells); but in man the effect on normal lymphoidtissue is modest. bronchoconstriction and renal vaso-dilatation are attenuated by pretreatment with PG synthesisinhibitors (aspirin).
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This is one of the many reasons why Tregproliferation under these conditions is a critical factor in not only the development of GVHD,but also the development of fibrotic tissue in the lungs and liver. Peacock AJ, Murphy NF, McMurray JJ, Caballero L, Stewart S.
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