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When most of thecells of the liver are involved, this is termed massive necrosis.As the name implies, this involves destruction of most or allof the hepatic acinus

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For eachchemical of interest, one needs an analytical chemistry pro-tocol to measure concentration of the parent in the mediumbeing studied using liquid chromatography/mass spectrom-etry (LC/MS) or gas chromatography/mass spectrometry(GC/MS).

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